Uni.-Prof. Dr. Joachim Matthias Johannes Geyer

Projekte als Projektleitung

  

  

  

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• Structure-based drug development of virus-selective HBV/HDV entry inhibitors by virtual screening in collaboration with the company ChemSpace
  01.07.2024 - 28.02.2026
  Hessisches Ministerium für Wissenschaft und Forschung, Kunst und Kultur (HMWK)
• Philipp Schwartz-Stipendium der Alexander von Humboldt-Stiftung/Verlängerung Prof. Dr. Emre Karakus
  01.08.2021 - 31.07.2022
  Alexander von Humboldt-Stiftung (AvH)
• Stipendium Emre Karakus - Scholar Rescue Fund
  01.08.2018 - 31.07.2019
  Justus-Liebig-Universität Gießen (JLU)
• Kooperationsvertrag BVL: Pharmakovigilanz – Instrument zur Überwachung und Betreuung von Tierarzneimitteln
  17.05.2018 - 17.05.2020
  Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (BVL)
• SFB 1021 TP B08* - RNA-Viren: Metabolismus viraler RNA, Immunantwort der Wirtszellen und virale Pathogenese - Teilprojekt: Interaktionen des Hepatitis-D-Virus (HDV) mit seinem Helfervirus (HBV) und seinem Rezeptor NTCP in einem in vitro Infektionsmodell
  01.01.2017 - 31.03.2021
  Deutsche Forschungsgemeinschaft (DFG)

Publikationen

  

  

  

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• Interactions of Na+/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy (2023)
  
  • Biological Chemistry
  Zakrzewicz, D; Geyer, J
  Journalartikel
• Role of the Sodium-Dependent Organic Anion Transporter (SOAT/SLC10A6) in Physiology and Pathophysiology (2023)
  
  • International Journal of Molecular Sciences
  Wannowius, M; Karakus, E; Aktürk, Z; et al.
  Journalartikel
• The Rauischholzhausen Transport Colloquium: membrane proteins from structure to function (2023)
  
  • Biological Chemistry
  Geyer, J; Hofmann, E; Schmitt, L
  Journalartikel
• Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters (2022)
  
  • International Journal of Molecular Sciences
  Meyer, MJ; Falk, S; Römer, S; et al.
  Journalartikel
• IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection (2022)2022)
  
  • Viruses
  Palatini, M; Müller, SF; Kirstgen, M; et al.
  Journalartikel
• Multitasking Na+/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery (Role of the Steroid Sulfate Uptake Transporter Soat (Slc10a6) in Adipose Tissue and 3T3-L1 Adipocytes (2022)
  
  • BiomedicinesFrontiers in Molecular Biosciences
  Zakrzewicz, D; Geyer, J
  Journalartikel
• Organic Cation Transporter I and Na+/taurocholate Co-Transporting Polypeptide are Involved in Retrorsine- and Senecionine-Induced Hepatotoxicity in HepaRG cells (2022)The orally available sodium/taurocholate co-transporting polypeptide inhibitor A2342 blocks hepatitis B and D entry in vitro (2022)
  
  • Molecular Nutrition & Food ResearchGut
  Enge, AM; Kaltner, F; Gottschalk, C; et al.
  Journalartikel
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  Karakus, E; Schmid, A; Leiting, S; et al.
  Journalartikel
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  Bonn, B; Strängberg, E; Uzelac, I; et al.
  Meeting Abstract
• The orally available sodium/taurocholate co-transporting polypeptide inhibitor A2342 blocks hepatitus B and D entry in vitro (2022)
  
  • Journal of Hepatology
  Bonn, B; Strängberg, E; Uzelac, I; et al.
  Konferenzposter
• Tyrosine 146 of the Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes (2022)
  
  • VirusesFrontiers in Molecular Biosciences
  Zakrzewicz, D; Leidolf, R; Kunz, S; et al.
  Journalartikel
• Urinary cortisol metabolites are reduced in MDR1 mutant dogs in a pilot targeted GC-MS urinary steroid hormone metabolome analysis (2022)
  
  • Journal of Veterinary Pharmacology and Therapeutics
  Gramer, I; Karakus, E; Hartmann, MF; et al.
  Journalartikel
• Detection of the ABCB11930_1931del TC Mutation in Two Suspected Ivermectin-Sensitive Cats and Their Relatives by a Novel TaqMan Allelic Discrimination Assay (2021)
  
  • Frontiers in Veterinary Science
  Nürnberger, D; Wagner, L; Müller, SF; et al.
  Journalartikel
• First Sequencing of Caprine Mdr1 (Abcb1) mRNA Due to Suspected Neurological Adverse Drug Reaction in a Thuringian Goat Following Extra-Label Use of Doramectin (2021)
  
  • Frontiers in Veterinary Science
  Nürnberger, D; Müller, SF; Hamann, M; et al.
  Journalartikel
• Functional Analysis of Rare Genetic Variants in the Negative Regulator of Intracellular Calcium Signaling RCAS/SLC10A7 (2021)
  
  Wannowius, M; Karakus, E; Geyer, J
  Journalartikel