Journal article

Publication year: 2006

Pages: 329-336

Journal: Soft Matter

Volume number: 2

Issue number: 4

ISSN: 1744-683X

DOI Link: https://doi.org/10.1039/b515626b

Publisher: Royal Society of Chemistry

Abstract: 
Here we show that ionic self-assembly of simple biological tectons can be Used to synthesize stable and highly ordered molecular structures. In particular, nucleotides and charged polypeptides can be assembled to form a complex analogous to DNA under relatively benign conditions. The combination of polylysine and pure dGMP leads to a fourfold ladder structure stabilizing all interior G-quartet structure by four polypeptide scaffolds. Making use of the Watson-Crick G:C base pairing motive leads to double-stranded complexes. Interestingly, these complexes show stable DNA-like organization ill aqueous solutions, as proven by gel electrophoresis and intercalation experiments.

Harvard Citation style: Ozer, B., Smarsly, B., Antonietti, M. and Faul, C. (2006) DNA-analogous structures from deoxynucleophosphates and polylysine by ionic self-assembly, Soft Matter, 2(4), pp. 329-336. https://doi.org/10.1039/b515626b

APA Citation style: Ozer, B., Smarsly, B., Antonietti, M., & Faul, C. (2006). DNA-analogous structures from deoxynucleophosphates and polylysine by ionic self-assembly. Soft Matter. 2(4), 329-336. https://doi.org/10.1039/b515626b