Journalartikel

Jahr der Veröffentlichung: 2011

Seiten: 6012-6042

Zeitschrift: Angewandte Chemie International Edition

Bandnummer: 50

Heftnummer: 27

ISSN: 1433-7851

DOI Link: https://doi.org/10.1002/anie.201006128

Verlag: Wiley

Abstract: 

Acyl transfer is at the heart of functional‐group transfers utilized
both in nature and in the chemical laboratory. Acylations are part of
the natural assembly machinery for the generation of complex molecules
and for energy transport in biological systems. The recognition of
covalent acyl–enzyme intermediates led to both mechanistic studies as
well as the development of biomimetic approaches. Consequently, chemists
first used the tools of nature in the form of enzymes and naturally
occurring alkaloids as catalysts, before eventually developing a large
variety of synthetic small molecules for selective acyl transfer. In
contrast to nature, chemists utilize acylation reactions as a practical
way for stereoselection and functional‐group protection. Indeed, the
number of studies concerning acyl transfer has significantly increased
over the last 15 years. This Review examines and highlights these recent
developments with the focus as given in the title.

Harvard-Zitierstil: Müller, C. and Schreiner, P. (2011) Organocatalytic Enantioselective Acyl Transfer onto Racemic as well as meso Alcohols, Amines, and Thiol, Angewandte Chemie International Edition, 50(27), pp. 6012-6042. https://doi.org/10.1002/anie.201006128

APA-Zitierstil: Müller, C., & Schreiner, P. (2011). Organocatalytic Enantioselective Acyl Transfer onto Racemic as well as meso Alcohols, Amines, and Thiol. Angewandte Chemie International Edition. 50(27), 6012-6042. https://doi.org/10.1002/anie.201006128