Journal article

Publication year: 2008

Pages: 1513-1516

Journal: Organic Letters

Volume number: 10

Issue number: 8

DOI Link: https://doi.org/10.1021/ol800149y

Publisher: American Chemical Society

Abstract: 

We present a mild and efficient method for the completely regioselective
alcoholysis of styrene oxides utilizing a cooperative Brønsted
acid-type organocatalytic system comprised of mandelic acid (1 mol %)
and N,N‘-bis-[3,5-bis-(trifluoromethyl)phenyl]-thiourea (1
mol %). Various styrene oxides are readily transformed into their
corresponding β-alkoxy alcohols in good to excellent yields at full
conversion. Simple aliphatic and sterically demanding, as well as
unsaturated and acid-sensitive alcohols can be employed.

Harvard Citation style: Weil, T., Kotke, M., Kleiner, C. and Schreiner, P. (2008) Cooperative Brønsted Acid-Type Organocatalysis:  Alcoholysis of Styrene Oxides, Organic Letters, 10(8), pp. 1513-1516. https://doi.org/10.1021/ol800149y

APA Citation style: Weil, T., Kotke, M., Kleiner, C., & Schreiner, P. (2008). Cooperative Brønsted Acid-Type Organocatalysis:  Alcoholysis of Styrene Oxides. Organic Letters. 10(8), 1513-1516. https://doi.org/10.1021/ol800149y