Journal article

Publication year: 2007

Pages: 1842-1851

Journal: Microbiology

Volume number: 153

ISSN: 1350-0872

Open access status: Bronze

DOI Link: https://doi.org/10.1099/mic.0.2006/004390-0

Publisher: Microbiology Society

Abstract: 
The genome of the facultatively photosynthetic bacterium Rhodobacter sphaeroides encodes three proteins of the photolyase/cryptochrome family. This paper shows that phrA (RSP2143) encodes a functional photolyase, which is an enzyme that repairs UV radiation-induced DNA damage in a blue light dependent manner. Expression of phrA is upregulated in response to light, with no photoreceptor or the photosynthetic electron transport being involved. The results reveal that singlet oxygen and hydrogen peroxide dependent signals are transmitted by the sigma(E) factor and the anti-sigma(E) factor ChrR affecting phrA expression, while superoxide anions do not stimulate phrA expression. Thus, the sigma(E) regulon is involved not only in the response to singlet oxygen but also in the hydrogen peroxide response.

Harvard Citation style: Hendrischk, A., Braatsch, S., Glaeser, J. and Klug, G. (2007) The phrA gene of Rhodobacter sphaeroides encodes a photolyase and is regulated by singlet oxygen and peroxide in a sigma(E)-dependent manner, Microbiology, 153, pp. 1842-1851. https://doi.org/10.1099/mic.0.2006/004390-0

APA Citation style: Hendrischk, A., Braatsch, S., Glaeser, J., & Klug, G. (2007). The phrA gene of Rhodobacter sphaeroides encodes a photolyase and is regulated by singlet oxygen and peroxide in a sigma(E)-dependent manner. Microbiology. 153, 1842-1851. https://doi.org/10.1099/mic.0.2006/004390-0