Journalartikel

Jahr der Veröffentlichung: 2011

Seiten: 1147-1158

Zeitschrift: Genes & Development

Bandnummer: 25

Heftnummer: 11

ISSN: 0890-9369

DOI Link: https://doi.org/10.1101/gad.623411

Verlag: Cold Spring Harbor Laboratory Press

Abstract: 
Different steps in gene expression are intimately linked. In Saccharomyces cerevisiae, the conserved TREX complex couples transcription to nuclear messenger RNA (mRNA) export. However, it is unknown how TREX is recruited to actively transcribed genes. Here, we show that the Prp19 splicing complex functions in transcription elongation. The Prp19 complex is recruited to transcribed genes, interacts with RNA polymerase II (RNAPII) and TREX, and is absolutely required for TREX occupancy at transcribed genes. Importantly, the Prp19 complex is necessary for full transcriptional activity. Taken together, we identify the Prp19 splicing complex as a novel transcription elongation factor that is essential for TREX occupancy at transcribed genes and that thus provides a novel link between transcription and messenger ribonucleoprotein (mRNP) formation.

Harvard-Zitierstil: Chanarat, S., Seizl, M. and Sträßer, K. (2011) The Prp19 complex is a novel transcription elongation factor required for TREX occupancy at transcribed genes, Genes & Development, 25(11), pp. 1147-1158. https://doi.org/10.1101/gad.623411

APA-Zitierstil: Chanarat, S., Seizl, M., & Sträßer, K. (2011). The Prp19 complex is a novel transcription elongation factor required for TREX occupancy at transcribed genes. Genes & Development. 25(11), 1147-1158. https://doi.org/10.1101/gad.623411