Journal article

Publication year: 2007

Pages: 2967-2972

Journal: Proceedings of the National Academy of Sciences

Volume number: 104

Issue number: 8

ISSN: 0027-8424

DOI Link: https://doi.org/10.1073/pnas.0609067104

Publisher: National Academy of Sciences

Abstract: 
The perception of odors is influenced by a variety of neuromodulators, and there is growing evidence that modulation already takes place in the olfactory epithelium. Here we report on cannabinergic actions in the olfactory epithelium of Xenopus laevis tadpoles. First we show that CB1 receptor-specific antagonists AM251, AM281, and LY320135 modulate odor-evoked calcium changes in olfactory receptor neurons. Second, we localize CB1-like immunoreactivity on dendrites of olfactory receptor neurons. Finally, we describe the cannabinergic influence on odor-induced spike-associated currents in individual olfactory receptor neurons. Here we demonstrate that the cannabinergic system has a profound impact on peripheral odor processing and discuss its possible function.

Harvard Citation style: Czesnik, D., Schild, D., Kuduz, J. and Manzini, I. (2007) Cannabinoid action in the olfactory epithelium, Proceedings of the National Academy of Sciences, 104(8), pp. 2967-2972. https://doi.org/10.1073/pnas.0609067104

APA Citation style: Czesnik, D., Schild, D., Kuduz, J., & Manzini, I. (2007). Cannabinoid action in the olfactory epithelium. Proceedings of the National Academy of Sciences. 104(8), 2967-2972. https://doi.org/10.1073/pnas.0609067104