Journal article

Purinergic receptor-mediated Ca2+ signaling in the olfactory bulb and the neurogenic area of the lateral ventricles


Authors listHassenklöver, T; Schulz, P; Peters, A; Schwartz, P; Schild, D; Manzini, I

Publication year2010

Pages429-445

JournalPurinergic Signalling

Volume number6

Issue number4

ISSN1573-9538

DOI Linkhttps://doi.org/10.1007/s11302-010-9207-6

PublisherSpringer


Abstract
Like in other vertebrates, the anterior part of the telencephalon of amphibians mainly consists of the olfactory bulb (OB), but different from higher vertebrates, the lateral telencephalic ventricles of larval Xenopus laevis expand deep into the anterior telencephalon. The neurogenic periventricular zone (PVZ) of the lateral ventricles generates new OB neurons throughout the animal's lifetime. We investigated the ultrastructural organization of the PVZ and found that within a time period of 24 h, 42.54 ± 6.65% of all PVZ cells were actively proliferating. Functional purinergic receptors are widespread in the central nervous system and their activation has been associated with many critical physiological processes, including the regulation of cell proliferation. In the present study we identified and characterized the purinergic system of the OB and the PVZ. ATP and 2MeSATP induced strong [Ca(2+)](i) increases in cells of both regions, which could be attenuated by purinergic antagonists. However, a more thorough pharmacological investigation revealed clear differences between the two brain regions. Cells of the OB almost exclusively express ionotropic P2X purinergic receptor subtypes, whereas PVZ cells express both ionotropic P2X and metabotropic P1 and P2Y receptor subtypes. The P2X receptors expressed in the OB are evidently not involved in the immediate processing of olfactory information.



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Citation Styles

Harvard Citation styleHassenklöver, T., Schulz, P., Peters, A., Schwartz, P., Schild, D. and Manzini, I. (2010) Purinergic receptor-mediated Ca2+ signaling in the olfactory bulb and the neurogenic area of the lateral ventricles, Purinergic Signalling, 6(4), pp. 429-445. https://doi.org/10.1007/s11302-010-9207-6

APA Citation styleHassenklöver, T., Schulz, P., Peters, A., Schwartz, P., Schild, D., & Manzini, I. (2010). Purinergic receptor-mediated Ca2+ signaling in the olfactory bulb and the neurogenic area of the lateral ventricles. Purinergic Signalling. 6(4), 429-445. https://doi.org/10.1007/s11302-010-9207-6


Last updated on 2025-21-05 at 13:20