Journalartikel

Jahr der Veröffentlichung: 1988

Seiten: 59-62

Zeitschrift: FEBS Letters

Bandnummer: 229

Heftnummer: 1

ISSN: 0014-5793

DOI Link: https://doi.org/10.1016/0014-5793(88)80797-X

Verlag: Wiley

Abstract: 

By crosslinking radioiodinated recombinant human IL1 α to mouse EL4 thymoma cells we have identified in addition to the known IL1‐binding proteins of 80 kDa, a second IL1‐binding protein of about 40 kDa. This second binding protein could be demonstrated most easily when crosslinking to higher protein complexes was inhibited. This finding suggests that the IL1 receptor, similar to the receptor for other cytokines such as interleukin 2, is composed of a heterodimer, of which both polypeptides contribute to ligand binding.By crosslinking radioiodinated recombinant human IL1 α to mouse EL4 thymoma cells we have identified in addition to the known IL1‐binding proteins of 80 kDa, a second IL1‐binding protein of about 40 kDa. This second binding protein could be demonstrated most easily when crosslinking to higher protein complexes was inhibited. This finding suggests that the IL1 receptor, similar to the receptor for other cytokines such as interleukin 2, is composed of a heterodimer, of which both polypeptides contribute to ligand binding.

Harvard-Zitierstil: Kroggel, R., Martin, M., Pingoud, V., Dayer, J. and Resch, K. (1988) 2-chain structure of the interleukin 1 receptor, FEBS Letters, 229(1), pp. 59-62. https://doi.org/10.1016/0014-5793(88)80797-X

APA-Zitierstil: Kroggel, R., Martin, M., Pingoud, V., Dayer, J., & Resch, K. (1988). 2-chain structure of the interleukin 1 receptor. FEBS Letters. 229(1), 59-62. https://doi.org/10.1016/0014-5793(88)80797-X