Journal article

Publication year: 2001

Pages: 65-68

Journal: FEBS Letters

Volume number: 499

Issue number: 1-2

ISSN: 0014-5793

DOI Link: https://doi.org/10.1016/S0014-5793(01)02515-7

Publisher: Wiley

Abstract: 
A preliminary model has been calculated for the activating interaction of the interleukin 1 receptor (IL-1R) accessory protein IL-1RAcP with the ligand/receptor complex IL-I beta /IL-1R(1). First, IL-1RAcP was modeled on the crystal structure of IL-1R(1) bound to IL-1 beta. Then, the IL-1RAcP model was docked using specific programs to the crystal structure of the IL-1 beta /IL-1R(1) complex. Two types Of models were predicted, with comparable probability, Experimental data obtained with the use of IL-1 beta peptides and antibodies, and with mutated IL-1 beta proteins, support the BACK model, in which IL-1RAcP establishes contacts with the bark of IL-1R(1) wrapped around IL-1 beta. (C) 2001 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.

Harvard Citation style: Casadio, R., Frigimelica, E., Bossu, P., Neumann, D., Martin, M., Tagliabue, A., et al. (2001) Model of interaction of the IL-1 receptor accessory protein IL-1RAcP with the IL-1 beta/IL-1R(I) complex, FEBS Letters, 499(1-2), pp. 65-68. https://doi.org/10.1016/S0014-5793(01)02515-7

APA Citation style: Casadio, R., Frigimelica, E., Bossu, P., Neumann, D., Martin, M., Tagliabue, A., & Boraschi, D. (2001). Model of interaction of the IL-1 receptor accessory protein IL-1RAcP with the IL-1 beta/IL-1R(I) complex. FEBS Letters. 499(1-2), 65-68. https://doi.org/10.1016/S0014-5793(01)02515-7