Journal article

Publication year: 2002

Pages: 52-58

Journal: Biochemical and Biophysical Research Communications

Volume number: 297

Issue number: 1

ISSN: 0006-291X

DOI Link: https://doi.org/10.1016/S0006-291X(02)02130-7

Publisher: Elsevier

Abstract: 
Interleukin-1 receptor-associated kinases (IRAKs) are pivotal signaling elements of the Toll/IL-1 receptor (TIL) family, which play a role in innate immune responses by coordinating host defence mechanisms. Presently four different forms of human IRAK molecules are cloned (hu-IRAK-1, hu-IRAK-2, hu-IRAK-M, and hu-IRAK-4). In the murine system, only three genes have been identified so far, mouse Pelle-Like Kinase (mPLK), which corresponds to human IRAK-1, mu-IRAK-M, and mu-IRAK-4. Here we report the molecular cloning and characterization of murine IRAK-2 (mu-IRAK-2), a mouse homolog to human IRAK-2 (hu-IRAK-2). Murine and human IRAK-2 molecules show 67% sequence identity, they are ubiquitiously expressed, and both practically lack autophoshorylation kinase activity. The murine molecule reveals two remarkable differences to its human counterpart: it shows a C-terminal extension and it has no stimulatory effect on IL-1 induced NF-kappaB activation when compared to hu-IRAK-2, suggesting subtle functional differences in signaling by IRAK-2 in human and mouse cells. (C) 2002 Elsevier Science (USA). All rights reserved.

Harvard Citation style: Rosati, O. and Martin, M. (2002) Identification and characterization of murine IRAK-2, Biochemical and Biophysical Research Communications, 297(1), pp. 52-58. https://doi.org/10.1016/S0006-291X(02)02130-7

APA Citation style: Rosati, O., & Martin, M. (2002). Identification and characterization of murine IRAK-2. Biochemical and Biophysical Research Communications. 297(1), 52-58. https://doi.org/10.1016/S0006-291X(02)02130-7