Journalartikel

Jahr der Veröffentlichung: 2016

Zeitschrift: BMC Cancer

Bandnummer: 16

Heftnummer: 1

ISSN: 1471-2407

eISSN: 1471-2407

Open Access Status: Gold

DOI Link: https://doi.org/10.1186/s12885-016-2087-6

Verlag: BioMed Central

Abstract: 

Dual specificity phosphatases are a class of tumor-associated proteins involved in the negative regulation of the MAP kinase pathway. Downregulation of the dual specificity phosphatase 2 (DUSP2) has been reported in cancer. Epigenetic silencing of tumor suppressor genes by abnormal promoter methylation is a frequent mechanism in oncogenesis. It has been shown that the epigenetic factor CTCF is involved in the regulation of tumor suppressor genes.

Harvard-Zitierstil: Haag, T., Richter, A., Schneider, M., Jimenez, A. and Dammann, R. (2016) The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms, BMC Cancer, 16(1), Article 49. https://doi.org/10.1186/s12885-016-2087-6

APA-Zitierstil: Haag, T., Richter, A., Schneider, M., Jimenez, A., & Dammann, R. (2016). The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms. BMC Cancer. 16(1), Article 49. https://doi.org/10.1186/s12885-016-2087-6