Journalartikel

Jahr der Veröffentlichung: 2014

Seiten: 792-799

Zeitschrift: Environmental Toxicology and Pharmacology

Bandnummer: 38

Heftnummer: 3

ISSN: 1382-6689

DOI Link: https://doi.org/10.1016/j.etap.2014.09.011

Verlag: Elsevier

Abstract: 
The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the antibiotic concentration in feces. Therefore, a new liquid-liquid extraction method combined with HPLC-MS/MS for the detection of marbofloxacin, ciprofloxacin, enrofloxacin and difloxacin in chicken feces was developed. Recoveries ranged from 51.0% to 83.5%. LOQs were between 0.10 and 1.09μg/kg. Feces of chickens treated with an enrofloxacin dosage of 10mg/kg bodyweight revealed maximum enrofloxacin and ciprofloxacin concentrations of 61.3 and 18.8mg/kg. Both antibiotics could be detected in feces up to two days after the last application in notable amounts (∼1mg/kg). Thus, feces of recently medicated chickens should not be used as a fertilizer without any further processing.

Harvard-Zitierstil: Janusch, F., Scherz, G., Mohring, S. and Hamscher, G. (2014) Determination of fluoroquinolones in chicken feces - A new liquid-liquid extraction method combined with LC-MS/MS, Environmental Toxicology and Pharmacology, 38(3), pp. 792-799. https://doi.org/10.1016/j.etap.2014.09.011

APA-Zitierstil: Janusch, F., Scherz, G., Mohring, S., & Hamscher, G. (2014). Determination of fluoroquinolones in chicken feces - A new liquid-liquid extraction method combined with LC-MS/MS. Environmental Toxicology and Pharmacology. 38(3), 792-799. https://doi.org/10.1016/j.etap.2014.09.011