An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast - Research portal of Justus Liebig University Giessen:

Journal article

An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast

Authors list: Rodríguez-Navarro, S; Sträßer, K; Hurt, E

Publication year: 2002

Pages: 438-442

Journal: EMBO Reports

Volume number: 3

Issue number: 5

ISSN: 1469-221X

DOI Link: https://doi.org/10.1093/embo-reports/kvf091

Publisher: Springer

Abstract:
Yra1p is an essential and conserved mRNA export factor in yeast. Strikingly, removal of the intron from YRA1 causes a dominant-negative growth phenotype and a concomitant inhibition of mRNA export. However, both defects are neutralized by replacement of the intron of YRA1 by a different intron. Significantly, Yra1p is overproduced in yeast when expressed from its intronless gene, but Yra1p levels are the same as the wild type when expressed from an intron-containing YRA1 gene. Thus, an intron in YRA1 controls Yra1p expression and mRNA export.

Authors/Editors

- Uni.-Prof. Dr. Katja Sträßer

Citation Styles

Harvard Citation style: Rodríguez-Navarro, S., Sträßer, K. and Hurt, E. (2002) An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast, EMBO Reports, 3(5), pp. 438-442. https://doi.org/10.1093/embo-reports/kvf091

APA Citation style: Rodríguez-Navarro, S., Sträßer, K., & Hurt, E. (2002). An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast. EMBO Reports. 3(5), 438-442. https://doi.org/10.1093/embo-reports/kvf091