Journalartikel

Jahr der Veröffentlichung: 1997

Seiten: 125-135

Zeitschrift: Cell and Tissue Research

Bandnummer: 1997

Heftnummer: 289

DOI Link: https://doi.org/10.1007/s004410050858

Verlag: Springer

Abstract: 

Structural changes resulting from fluoride-induced disturbances of the
secretory stage of amelogenesis were studied in fluorosed dental enamel
of ten permanent premolars and molars from roe deer (Capreolus capreolus) and red deer (Cervus elaphus).
The fluorosed enamel exhibited surface hypoplasias of different depths
and extents and an associated loss of its normal prism/interprism
structure. The occurrence of such aprismatic enamel either was
restricted to grossly accentuated and hypomineralized incremental
(calciotraumatic) bands or affected more extended areas to the bottom of
the hypoplastic lesions. The fluoride-induced disturbance of the
secretory functions of the cells had thus been either temporary or
permanent. Layers of aprismatic enamel were regarded as denoting periods
of reduced enamel matrix formation by secretory ameloblasts lacking the
distal, i.e., the prism-forming, portions of their Tomes processes. Our
observations also indicated that the transition from the presecretory
to the secretory stage of amelogenesis could be affected by fluoride,
thereby preventing the ameloblasts from achieving their normal secretory
function and from establishing fully formed Tomes processes. Aprismatic
enamel was formed throughout the secretory stage of amelogenesis at
these locations. The most severe ameloblast reaction that could be
deduced from our findings was an abrupt cessation of enamel matrix
secretion. Some of the pathological changes observed in fluorosed deer
enamel showed striking similarities to those reported in rodents after
acute parenteral fluoride dosing. Thus, periods of especially elevated
plasma-fluoride levels in chronically fluoride-stressed deer can cause a
disruption in the function of secretory ameloblasts similar to that
following acute fluoride dosing in rodents.

Harvard-Zitierstil: Kierdorf, H. and Kierdorf, U. (1997) Disturbances of the secretory stage of amelogenesis in fluorosed deer teeth: a scanning electron-microscopic study, Cell and Tissue Research, 1997(289), pp. 125-135. https://doi.org/10.1007/s004410050858

APA-Zitierstil: Kierdorf, H., & Kierdorf, U. (1997). Disturbances of the secretory stage of amelogenesis in fluorosed deer teeth: a scanning electron-microscopic study. Cell and Tissue Research. 1997(289), 125-135. https://doi.org/10.1007/s004410050858