Journalartikel

Jahr der Veröffentlichung: 2015

Seiten: 87-92

Zeitschrift: Journal of Molecular Catalysis B: Enzymatic

Bandnummer: 122

ISSN: 1381-1177

DOI Link: https://doi.org/10.1016/j.molcatb.2015.08.002

Verlag: Elsevier

Abstract: 
The potential of basidiomycetous enzymes for selective alkane CH-functionalizations in aqueous media has been disclosed utilizing surface and submerged cultures. A screening displayed the high catalytic activity of Dichomitus albidofuscus, Pholiota squarrosa, and Abortiporus biennis in aerobic oxidations of adamantane as a model hydrocarbon. With isopropanol as a co-solvent, the oxidation was accelerated significantly without changes of the fungal growth. 1-Adamantanol was obtained in 40% preparative yield from the oxidation of adamantane by D. albidofuscus. The CH-positional selectivity (3 degrees/2 degrees =3.6) and the deuterium kinetic isotopic effect (k(H)/k(D) =2.25) values provide evidence for the participation of fungal metalloenzymes in the CH-activation step.

Harvard-Zitierstil: Zhuk, T., Goldmann, M., Hofmann, J., Pohl, J. and Zorn, H. (2015) Preparative aerobic oxidations with basidiomycetous enzymes: CH-functionalization of adamantane, Journal of Molecular Catalysis B: Enzymatic, 122, pp. 87-92. https://doi.org/10.1016/j.molcatb.2015.08.002

APA-Zitierstil: Zhuk, T., Goldmann, M., Hofmann, J., Pohl, J., & Zorn, H. (2015). Preparative aerobic oxidations with basidiomycetous enzymes: CH-functionalization of adamantane. Journal of Molecular Catalysis B: Enzymatic. 122, 87-92. https://doi.org/10.1016/j.molcatb.2015.08.002