Journalartikel

Jahr der Veröffentlichung: 2008

Seiten: 2339-2345

Zeitschrift: Journal of Separation Science

Bandnummer: 31

Heftnummer: 13

ISSN: 1615-9306

DOI Link: https://doi.org/10.1002/jssc.200800185

Verlag: Wiley-VCH Verlag

Abstract: 
The ability of crystalline degradation products (CDPs) of vancomycin as a chiral stationary phase was reported in a previous study for enantioselective separation of drugs, amino acids and agrochemical toxins by conventional LC column (250 x 4.6 mm). In this work, the potential of CDP of vancomycin for the enantiomeric separation in micro-LC (200 x 1 mm) has been studied. The obtained separation results are better than in our previous study with conventional LC columns. The enantiomers of D,L-phenylalanine, D,L-alanine, methyldopa, atropine and propranolol were used for this evaluation. Experiments have been carried out in a stainless steel tube that was packed with chiral silica particles of 3 and 12 mu m diameters. Also, three different ratios of 3 and 12 pm silica particles were used for packing material of chiral columns and the effect on aspect ratio and resolving powers was compared.

Harvard-Zitierstil: Ghassempour, A., Alizadeh, R., Najafi, N., Karami, A., Römpp, A., Spengler, B., et al. (2008) Crystalline degradation products of vancomycin as chiral stationary phase in microcolumn liquid chromatography, Journal of Separation Science, 31(13), pp. 2339-2345. https://doi.org/10.1002/jssc.200800185

APA-Zitierstil: Ghassempour, A., Alizadeh, R., Najafi, N., Karami, A., Römpp, A., Spengler, B., & Aboul-Enein, H. (2008). Crystalline degradation products of vancomycin as chiral stationary phase in microcolumn liquid chromatography. Journal of Separation Science. 31(13), 2339-2345. https://doi.org/10.1002/jssc.200800185