Contribution in an anthology

Appeared in: Proteome Research: Mass Spectrometry

Editor list: James, P

Publication year: 2001

Pages: 33-53

ISBN: 978-3-540-67256-2

eISBN: 978-3-642-56895-4

DOI Link: https://doi.org/10.1007/978-3-642-56895-4_3

Edition: 1. Auflage

Title of series: Principles and practice

Abstract: 

Mass spectrometry (MS) has changed its appearance in the scientific world considerably during recent years. MS started out as a tool in atomic physics approximately 100 years ago and has gradually been applied to the life sciences. Less than 20 years ago, a new ionisation method, fast atom bombardment, made MS a viable tool in the field of biochemistry (Barber et al. 1981). Approximately 10 years ago, with the invention of electrospray ionisation (ESI; Fenn et al. 1989) and matrix-assisted laser desorption ionisation (MALDI; Karas and Hillenkamp 1988), MS became a major tool for biology, biomedi-cine and molecular medicine. The impressive progress of MS can be summarised by plotting two methodological parameters of MS, accessible mass range and sensitivity, against one another (Fig. 3.1). The dramatic extension of mass range and sensitivity due to the development of ESI and MALDI were two of the essential prerequisites for the use of MS in the field of modern biology.

Harvard Citation style: Spengler, B. (2001) The Basics of Matrix-Assisted Laser Desorption, Ionisation Time-of-Flight Mass Spectrometry and Post-Source Decay Analysis, in James, P. (ed.) Proteome Research: Mass Spectrometry. 1. Auflage. Heidelberg: Springer Verlag, pp. 33-53. https://doi.org/10.1007/978-3-642-56895-4_3

APA Citation style: Spengler, B. (2001). The Basics of Matrix-Assisted Laser Desorption, Ionisation Time-of-Flight Mass Spectrometry and Post-Source Decay Analysis. In James, P. (Ed.), Proteome Research: Mass Spectrometry (1. Auflage, pp. 33-53). Springer Verlag. https://doi.org/10.1007/978-3-642-56895-4_3