Journalartikel

Jahr der Veröffentlichung: 2015

Seiten: 81-97

Zeitschrift: Organic & Biomolecular Chemistry

Bandnummer: 13

Heftnummer: 1

Open Access Status: Green

DOI Link: https://doi.org/10.1039/C4OB01339E

Verlag: Royal Society of Chemistry

Abstract: 

The mucin MUC1 is a glycoprotein involved in fundamental biological
processes, which can be found over-expressed and with a distinctly
altered glycan pattern on epithelial tumor cells; thus it is a promising
target structure in the quest for effective carbohydrate-based cancer
vaccines and immunotherapeutics. Natural glycopeptide antigens indicate
only a low immunogenicity and a T-cell independent immune response;
however, this major drawback can be overcome by coupling of glycopeptide
antigens multivalently to immunostimulating carrier platforms. In
particular, gold nanoparticles are well suited as templates for the
multivalent presentation of glycopeptide antigens, due to their
remarkably high surface-to-volume ratio in combination with their high
biostability. In this work the synthesis of novel MUC1-glycopeptide
antigens and their coupling to gold nanoparticles of different sizes are
presented. In addition, the development of a new dot-blot immunoassay
to test the potential antigen–antibody binding is introduced.

Harvard-Zitierstil: Tavernaro, I., Hartmann, S., Sommer, L., Hausmann, H., Rohner, C., Rühl, M., et al. (2015) Synthesis of tumor-associated MUC1-glycopeptides and their multivalent presentation by functionalized gold colloids, Organic and Biomolecular Chemistry, 13(1), pp. 81-97. https://doi.org/10.1039/C4OB01339E

APA-Zitierstil: Tavernaro, I., Hartmann, S., Sommer, L., Hausmann, H., Rohner, C., Rühl, M., Hoffmann-Röder, A., & Schlecht, S. (2015). Synthesis of tumor-associated MUC1-glycopeptides and their multivalent presentation by functionalized gold colloids. Organic and Biomolecular Chemistry. 13(1), 81-97. https://doi.org/10.1039/C4OB01339E