Journal article

Publication year: 2014

Pages: 550-562

Journal: RNA Biology

Volume number: 11

Issue number: 5

Open access status: Green

DOI Link: https://doi.org/10.4161/rna.29625

Publisher: Taylor and Francis Group

Abstract: 

The symbiotic α-rhizobia Sinorhizobium meliloti, Bradyrhizobium japonicum, Rhizobium etli and the related plant pathogen Agrobacterium tumefaciens
are important model organisms for studying plant-microbe interactions.
These metabolically versatile soil bacteria are characterized by complex
lifestyles and large genomes. Here we summarize the recent knowledge on
their small non-coding RNAs (sRNAs) including conservation, function,
and interaction of the sRNAs with the RNA chaperone Hfq. In each of
these organisms, an inventory of hundreds of cis- and trans-encoded
sRNAs with regulatory potential was uncovered by high-throughput
approaches and used for the construction of 39 sRNA family models.
Genome-wide analyses of hfq mutants and co-immunoprecipitation
with tagged Hfq revealed a major impact of the RNA chaperone on the
physiology of plant-associated α-proteobacteria including symbiosis and
virulence. Highly conserved members of the SmelC411 family are the AbcR
sRNAs, which predominantly regulate ABC transport systems. AbcR1 of A. tumefaciens
controls the uptake of the plant-generated signaling molecule GABA and
is a central regulator of nutrient uptake systems. It has similar
functions in S. meliloti and the human pathogen Brucella abortus.
As RNA degradation is an important process in RNA-based gene
regulation, a short overview on ribonucleases in plant-associated
α-proteobacteria concludes this review.

Harvard Citation style: Becker, A., Overlöper, A., Schlüter, J., Reinkensmeier, J., Robledo, M., Giegerich, R., et al. (2014) Riboregulation in plant-associated α-proteobacteria, RNA Biology, 11(5), pp. 550-562. https://doi.org/10.4161/rna.29625

APA Citation style: Becker, A., Overlöper, A., Schlüter, J., Reinkensmeier, J., Robledo, M., Giegerich, R., Narberhaus, F., & Evguenieva-Hackenberg, E. (2014). Riboregulation in plant-associated α-proteobacteria. RNA Biology. 11(5), 550-562. https://doi.org/10.4161/rna.29625