Sammelbandbeitrag

Erschienen in: RNA Exosome

Herausgeberliste: Jensen, TH

Jahr der Veröffentlichung: 2011

Seiten: 29-38

ISBN: 978-1-4419-7840-0

eISBN: 978-1-4419-7841-7

DOI Link: https://doi.org/10.1007/978-1-4419-7841-7_3

Serientitel: Advances in Experimental Medicine and Biology

Serienzählung: 702

Abstract: 

The archaeal exosome is a protein complex with structural similarities
to the eukaryotic exosome and bacterial PNPase. Its catalytic core is
formed by alternating Rrp41 and Rrp42 polypeptides, arranged in a
hexameric ring. A flexible RNA binding cap composed of the
evolutionarily conserved proteins Rrp4 and/or Csl4 is bound at the top
of the ring and seems to be involved in recruitment of specific
substrates and their unwinding. Additionally, the protein complex
contains an archaea-specific subunit annotated as DnaG, the function of
which is still unknown. The archaeal exosome degrades RNA
phosphorolytically in 3′ to 5′ direction. In a reverse reaction, it
synthesizes heteropolymeric RNA tails using nucleoside diphosphates. The
functional similarity between the archaeal exosome and PNPase shows
that important processes of RNA degradation and posttranscriptional
modification in Archaea are similar to the processes in Bacteria and
organelles.

Harvard-Zitierstil: Evguenieva-Hackenberg, E. (2011) The Archaeal Exosome, in Jensen, T. (ed.) RNA Exosome. New York: Springer, pp. 29-38. https://doi.org/10.1007/978-1-4419-7841-7_3

APA-Zitierstil: Evguenieva-Hackenberg, E. (2011). The Archaeal Exosome. In Jensen, T. (Ed.), RNA Exosome (pp. 29-38). Springer. https://doi.org/10.1007/978-1-4419-7841-7_3