Journalartikel

Jahr der Veröffentlichung: 1989

Seiten: 1887-1894

Zeitschrift: The Journal of Immunology

Bandnummer: 142

Heftnummer: 6

ISSN: 0022-1767

URL: http://www.jimmunol.org/content/142/6/1887

Verlag: American Association of Immunologists

Abstract: 

Glomerular mesangial cells (MC) were isolated from rats and cultured for a prolonged period of time, resulting in a homogeneous cell population. MC were characterized as belonging to the smooth muscle type. They were negative for MHC class II expression. IFN-gamma and TNF alpha suppressed the proliferation of MC, demonstrating receptors for these cytokines on MC. IFN-gamma or TNF alpha, respectively, enhanced basal MHC class I Ag expression of proliferating cells in culture. The combination of the two cytokines yielded stronger effects. IL-1 beta was ineffective in enhancing MHC class I Ag expression, although MC possessed receptors for this cytokine. IFN-gamma dose dependently induced the expression of MHC class II Ag, while TNF alpha or IL-1 beta were ineffective alone. The combination of IFN-gamma with TNF alpha or IL-1 beta resulted in an enhanced induction of MHC class II Ag, compared to IFN-gamma administration alone. These findings suggest that proliferating mesangial cells of the smooth muscle type may participate in local inflammatory responses or substitute for macrophages by meeting the accessory cell requirement in the interaction with T lymphocytes. Furthermore, the data have important implications for the evaluation of the role of mesangial cells in autoimmune disease of the kidney.

Harvard-Zitierstil: Martin, M., Schwinzer, R., Schellenkens, H. and Resch, K. (1989) Glomerular mesangial cells in local inflammation : Induction of the expression of MHC class II antigens by IFN-gamma, The Journal of Immunology, 142(6), pp. 1887-1894. http://www.jimmunol.org/content/142/6/1887

APA-Zitierstil: Martin, M., Schwinzer, R., Schellenkens, H., & Resch, K. (1989). Glomerular mesangial cells in local inflammation : Induction of the expression of MHC class II antigens by IFN-gamma. The Journal of Immunology. 142(6), 1887-1894. http://www.jimmunol.org/content/142/6/1887