Journal article

Publication year: 1994

Pages: 406-412

Journal: The Journal of Rheumatology

Volume number: 21

Issue number: 3

ISSN: 0315-162X

Publisher: The Journal of Rheumatology

Abstract: 
OBJECTIVES:To study the role of cytokines on adhesion molecule expression and binding of activated T cells to synovial type B cells. METHODS:Adhesion molecule expression was examined by immunofluorescence and adhesion of 51Cr-labelled T cells to the synovial cells determined.RESULTS:Tumor necrosis factor alpha/interferon gamma (TNF alpha/IFN-gamma) and interleukin 1 alpha (IL-1 alpha)/IFN-gamma enhanced adhesion molecule expression and the adhesion of T cells to synovial cells. Anti-intercellular adhesion molecule 1 blocked adhesion of T cells to TNF alpha/IFN-gamma and IL-1 alpha/IFN-gamma stimulated synovial cells while an antibody to CD61 blocked adhesion to IL-1 alpha/IFN-gamma stimulated cells.CONCLUSIONS:The interaction of leukocytes with adhesion molecules on synovial cells may play a role in recruitment of these cells to an inflammatory site.

Harvard Citation style: Cicuttini, F., Martin, M. and Boyd, A. (1994) Cytokine induction of adhesion molecules on synovial type B cells, The Journal of Rheumatology, 21(3), pp. 406-412

APA Citation style: Cicuttini, F., Martin, M., & Boyd, A. (1994). Cytokine induction of adhesion molecules on synovial type B cells. The Journal of Rheumatology. 21(3), 406-412.