Journal article
Authors list: Janzen, CJ; Fernandez, JP; Deng, HT; Diaz, R; Hake, SB; Cross, GAM
Publication year: 2006
Pages: 2306-2310
Journal: FEBS Letters
Volume number: 580
Issue number: 9
ISSN: 0014-5793
DOI Link: https://doi.org/10.1016/j.febslet.2006.03.044
Publisher: Wiley
Abstract:
To start to understand the role of chromatin structure in regulating transcription in trypanosomes, we analyzed covalent modifications on the four core histones of Trypanosoma brucei. We found unusually few modifications in the N-terminal tails, which are abundantly modified in other organisms and whose sequences, but not composition, are highly divergent in trypanosomes. In contrast, the C-terminal region of H2A appears to be hyper-acetylated. Surprisingly, the N-terminal alanines of H2A, H2B, and H4, were mono-methylated, a modification that has not been described previously for histones. Possible functions and evolutionary explanations for these unusual histone modifications are discussed.
Citation Styles
Harvard Citation style: Janzen, C., Fernandez, J., Deng, H., Diaz, R., Hake, S. and Cross, G. (2006) Unusual histone modifications in Trypanosoma brucei, FEBS Letters, 580(9), pp. 2306-2310. https://doi.org/10.1016/j.febslet.2006.03.044
APA Citation style: Janzen, C., Fernandez, J., Deng, H., Diaz, R., Hake, S., & Cross, G. (2006). Unusual histone modifications in Trypanosoma brucei. FEBS Letters. 580(9), 2306-2310. https://doi.org/10.1016/j.febslet.2006.03.044
