Journalartikel

Jahr der Veröffentlichung: 2005

Seiten: 1613-1622

Zeitschrift: Life Sciences

Bandnummer: 76

Heftnummer: 14

ISSN: 0024-3205

DOI Link: https://doi.org/10.1016/j.lfs.2004.08.027

Verlag: Elsevier

Abstract: 
14-Hydroxy-retro-retinol was previously described as an in vivo and in vitro metabolite of retinol. Furthermore, the retinoid 4-hydroxy-retinol was identified as an endogenous occurring retinoid in the amphibian organism and an in vitro metabolite of retinol. We describe in the present study that 14-hydroxy-retro-retinol and 4-hydroxy-retinol are present in normal neonatal rat serum as endogenous occurring retinoids in normal non-vitamin A supplemented mammals (rats). Both retinoids were detected in serum and liver of neonatal rats at days 3 and 11 after birth. The respective concentrations at day 11 after birth were 41.8 +/- 2.8 ng/ml (serum)/ 104 +/- 6 ng/g (liver) for 4-hydroxy-retinol and 23 +/- 4.6 ng/ml (serum)/ 285 +/- 5 ng/g (liver) for 14-hydroxy-retro-retinol. Both retinoids could not be detected in adult rat serum and liver. From our experiments important physiological functions of these retinoids during postnatal development could be postulated.

Harvard-Zitierstil: Rühl, R., Hamscher, G., Garcia, A., Nau, H. and Schweigert, F. (2005) Identification of 14-hydroxy-retro-retinol and 4-hydroxy-retinol as endogenous retinoids in rats throughout neonatal development, Life Sciences, 76(14), pp. 1613-1622. https://doi.org/10.1016/j.lfs.2004.08.027

APA-Zitierstil: Rühl, R., Hamscher, G., Garcia, A., Nau, H., & Schweigert, F. (2005). Identification of 14-hydroxy-retro-retinol and 4-hydroxy-retinol as endogenous retinoids in rats throughout neonatal development. Life Sciences. 76(14), 1613-1622. https://doi.org/10.1016/j.lfs.2004.08.027