Journal article

Publication year: 2013

Pages: 360-366

Journal: Medicinal Chemistry Research

Volume number: 22

Issue number: 1

DOI Link: https://doi.org/10.1007/s00044-012-0029-7

Publisher: Springer

Abstract: 

Computational modeling demonstrates that the van-der-Waals surfaces of homocubyl amines are similar to that of the neuroprotector Memantine^®. Utilizing readily available precursors we report the preparation of a series of homological cubylamines, namely
pentacyclo[6.3.0.0^2,6.0^3,10.0^5,9]undecyl-4-amine (trishomocubyl-4-amine, 2), pentacyclo[5.3.0.0^2,5.0^3,9.0^4,8]decyl-10-amine (bishomocubyl-10-amine, 3), pentacyclo[4.3.0.0^2,5.0^3,8.0^4,7]nonyl-9-amine (homocubyl-9-amine, 4), and pentacyclo[4.2.0.0^2,5.0^3,8.0^4,7]octyl-1-amine (cubylamine, 5). The hydrochlorides of amines 2–5 show pronounced affinity for the (+)MK-801 channel binding site, and it seems likely that these compounds would act as very fast voltage-dependent NMDA receptor antagonists.

Harvard Citation style: Sklyarova, A., Rodionov, V., Parsons, C., Quack, G., Schreiner, P. and Fokin, A. (2013) Preparation and testing of homocubyl amines as therapeutic NMDA receptor antagonists, Medicinal Chemistry Research, 22(1), pp. 360-366. https://doi.org/10.1007/s00044-012-0029-7

APA Citation style: Sklyarova, A., Rodionov, V., Parsons, C., Quack, G., Schreiner, P., & Fokin, A. (2013). Preparation and testing of homocubyl amines as therapeutic NMDA receptor antagonists. Medicinal Chemistry Research. 22(1), 360-366. https://doi.org/10.1007/s00044-012-0029-7