Journalartikel

Jahr der Veröffentlichung: 2000

Seiten: 695-706

Zeitschrift: Journal of Cell Biology

Bandnummer: 150

Heftnummer: 4

ISSN: 0021-9525

DOI Link: https://doi.org/10.1083/jcb.150.4.695

Verlag: Rockefeller University Press

Abstract: 
It is not known how Mex67p and Mtr2p, which form a heterodimer essential for mRNA export, transport mRNPs through the nuclear pore. Here, we show that the Mex67p/Mtr2p complex binds to all of the repeat types (GLFG, FXFG, and FG) found in nucleoporins. For this interaction, complex formation between Mex67p and Mtr2p has to occur. MEX67 and MTR2 also genetically interact with different types of repeat nucleoporins, such as Nup116p, Nup159p, Nsp1p, and Rip1p/Nup40p. These data suggest a model in which nuclear mRNA export requires the Mex67p/Mtr2p heterodimeric complex to directly contact several repeat nucleoporins, organized in different nuclear pore complex subcomplexes, as it carries the mRNP cargo through the nuclear pore.

Harvard-Zitierstil: Sträßer, K., Baßler, J. and Hurt, E. (2000) Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export., Journal of Cell Biology, 150(4), pp. 695-706. https://doi.org/10.1083/jcb.150.4.695

APA-Zitierstil: Sträßer, K., Baßler, J., & Hurt, E. (2000). Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export.. Journal of Cell Biology. 150(4), 695-706. https://doi.org/10.1083/jcb.150.4.695