Journal article

Publication year: 2003

Pages: 375-385

Journal: The Journal of Physiology

Volume number: 546

Issue number: 2

ISSN: 0022-3751

DOI Link: https://doi.org/10.1113/jphysiol.2002.033175

Publisher: Wiley

Abstract: 
Olfactory receptor neurons (ORNs) are the only class of neurons that is directly exposed to the environment. Therefore, they need to deal with xenobiotic and potentially cytotoxic substances. Here we show for the first time that ORNs possess transporter systems that expel xenobiotics across the plasma membrane. Using calcein and calcium-indicator dyes as xenobiotics, we demonstrate that ORNs appear to express the multidrug resistance P-glycoprotein (MDR1) and multidrug resistance-associated proteins (MRP). This endows ORNs with the ability to transport a large number of substrates including calcium-indicator dyes and calcein across their plasma membranes. Conversely, blocking P-glycoprotein and MRP increases the net uptake of these dyes.

Harvard Citation style: Manzini, I. and Schild, D. (2003) Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles, The Journal of Physiology, 546(2), pp. 375-385. https://doi.org/10.1113/jphysiol.2002.033175

APA Citation style: Manzini, I., & Schild, D. (2003). Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles. The Journal of Physiology. 546(2), 375-385. https://doi.org/10.1113/jphysiol.2002.033175