Journal article

Publication year: 2010

Pages: 8965-8973

Journal: The Journal of Neuroscience

Volume number: 30

Issue number: 26

ISSN: 0270-6474

DOI Link: https://doi.org/10.1523/JNEUROSCI.4030-09.2010

Publisher: Society for Neuroscience

Abstract: 
Cannabinoids modulate the activity of many neuronal cells, among them sensory neurons in the olfactory epithelium. Here we show that the endocannabinoid 2-arachidonoyl-glycerol (2-AG) is synthesized in both olfactory receptor neurons and glia-like sustentacular cells in larval Xenopus laevis. Its production in the latter depends on the hunger state of the animal. The essential effect of 2-AG in olfactory receptor neurons is the control of odorant detection thresholds via cannabinoid CB(1) receptor activation. Hunger renders olfactory neurons more sensitive. Endocannabinoid modulation in the nose may therefore substantially influence food-seeking behavior.

Harvard Citation style: Breunig, E., Manzini, I., Piscitelli, F., Gutermann, B., Di Marzo, V., Schild, D., et al. (2010) The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis, The Journal of Neuroscience, 30(26), pp. 8965-8973. https://doi.org/10.1523/JNEUROSCI.4030-09.2010

APA Citation style: Breunig, E., Manzini, I., Piscitelli, F., Gutermann, B., Di Marzo, V., Schild, D., & Czesnik, D. (2010). The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. The Journal of Neuroscience. 30(26), 8965-8973. https://doi.org/10.1523/JNEUROSCI.4030-09.2010