Journalartikel

Jahr der Veröffentlichung: 2004

Seiten: 463-474

Zeitschrift: Anatomy and Embryology

Bandnummer: 207

Heftnummer: 6

ISSN: 0340-2061

DOI Link: https://doi.org/10.1007/s00429-003-0368-8

Verlag: Springer Verlag

Abstract: 

We studied the structural changes in the enamel of mandibular third
molars of miniature pigs administered a daily oral dose of 2 mg NaF
(approximately 0.9 mg of fluoride) per kg body weight (added to the
feed) for 1 year. The treatment period covered most of the secretory
stage and the entire post-secretory stage of amelogenesis of the M₃.
The enamel of the molars from the fluoride-fed pigs appeared opaque and
chalky, and the erupted portions were stained brown. The underlying
histopathological change was a pronounced subsurface hypomineralization
of the enamel beneath a thin surface rim of higher mineral content. This
enamel hypomineralization was attributed to a fluoride-induced
impairment of the process of enamel maturation. The most conspicuous
finding in the fluorotic enamel was the presence of numerous pit-type
hypoplastic defects, denoting a marked fluoride-induced disturbance also
of the secretory stage of amelogenesis. Microradiography and scanning
electron microscopy revealed an enhanced incremental pattern in the
outer enamel of the fluorotic molars. Typically, the bottom of larger
hypoplastic defects was underlain by a broad, grossly accentuated
incremental line. Occurrence of larger hypoplasias was further
associated with the presence of aprismatic enamel, the formation of
which was attributed to a loss of the prism-forming (distal) portion of
the Tomes’ processes of secretory ameloblasts. The findings in the
miniature pigs closely parallel earlier observations on fluorotic enamel
of free-ranging deer and wild boar from fluoride-polluted areas.

Harvard-Zitierstil: Kierdorf, H., Kierdorf, U., Richards, A. and Josephsen, K. (2004) Fluoride-induced alterations of enamel structure: an experimental study in the miniature pig, Anatomy and Embryology, 207(6), pp. 463-474. https://doi.org/10.1007/s00429-003-0368-8

APA-Zitierstil: Kierdorf, H., Kierdorf, U., Richards, A., & Josephsen, K. (2004). Fluoride-induced alterations of enamel structure: an experimental study in the miniature pig. Anatomy and Embryology. 207(6), 463-474. https://doi.org/10.1007/s00429-003-0368-8