Journal article

Publication year: 1999

Pages: 511-513

Journal: British Journal of Haematology

Volume number: 105

Issue number: 2

ISSN: 0007-1048

DOI Link: https://doi.org/10.1111/j.1365-2141.1999.01328.x

Publisher: Wiley

Abstract: 
Serum concentrations of the thrombopoiesis-enhancing cytokines thrombopoietin (TPO), erythropoietin (EPO), interleukin (IL)-6 and IL-11 were determined in 119 healthy whole-blood (WBD) and 101 platelet donors (PD) prior to donation. The 90% TPO reference interval in WED of 64-867 pg/ml (median 163, 100% range 45-7572) was significantly higher than in PD of 56-524 (median 122, range 44-801, P = 0.004), whereas their platelet counts were lower (P = 0.001). EPO levels were not different (WBD 7.7 +/- 3.8, PD 8.0 +/- 4.9 IU/l), IL-6 and IL-11 were below the detection limit in greater than or equal to 90% of cases (IL-6 < 3.2 pg/ml, IL-11 < 31.2 pg/ml). None of the cytokines correlated with platelet counts, other blood parameters, or in the PD group with the frequency of platelet donations within the last 6 months. We conclude that plateletpheresis does not lead to a lasting increase of thrombopoietic cytokines and provide reference data for potential platelet mobilization strategies with recombinant growth factors.

Harvard Citation style: Tacke, F., Schöffski, P., Trautwein, C., Martin, M., Stangel, W., Seifried, E., et al. (1999) Endogenous serum levels of thrombopoietic cytokines in healthy whole-blood and platelet donors: implications for plateletpheresis, British Journal of Haematology, 105(2), pp. 511-513. https://doi.org/10.1111/j.1365-2141.1999.01328.x

APA Citation style: Tacke, F., Schöffski, P., Trautwein, C., Martin, M., Stangel, W., Seifried, E., Manns, M., Ganser, A., & Petersen, D. (1999). Endogenous serum levels of thrombopoietic cytokines in healthy whole-blood and platelet donors: implications for plateletpheresis. British Journal of Haematology. 105(2), 511-513. https://doi.org/10.1111/j.1365-2141.1999.01328.x