Journal article
Authors list: Falgenhauer, L; Imirzalioglu, C; Ghosh, H; Gwozdzinski, K; Schmiedel, J; Gentil, K; Bauerfeind, R; Kämpfer, P; Seifert, H; Michael, GB; Schwarz, S; Pfeifer, Y; Werner, G; Pietsch, M; Roesler, U; Guerra, B; Fischer, J; Sharp, H; Käsbohrer, A; ; Goesmann, A; Hille, K; Kreienbrock, L; Chakraborty, T
Publication year: 2016
Pages: 457-465
Journal: International Journal of Antimicrobial Agents
Volume number: 47
Issue number: 6
ISSN: 0924-8579
DOI Link: https://doi.org/10.1016/j.ijantimicag.2016.03.019
Publisher: Elsevier
Abstract:
Multidrug-resistant Escherichia coli encoding CTX-M-type extended-spectrum β-lactamases (ESBLs) are isolated in increasing numbers from humans, companion animals and livestock, raising concern regarding the exchange and spread of isolates in these populations. In this study, whole-genome sequencing of CTX-M-15-producing E. coli isolates recently sampled from humans, companion animals, livestock and farm environments was performed. In total, 26 different sequence types (STs) were detected, of which ST410 was the most frequent and was the only ST present in all populations studied. Five clades (designated A-E) were detected within the ST410 isolates. In particular, isolates of clade B were present in all four populations and had core genomes that differed by less than 70 single nucleotide polymorphisms (SNPs). Isolates of clades B and C were also clonally marked, exhibiting identical chromosomal insertions of blaCTX-M-15 at distinct loci. These data provide strong evidence for the clonal dissemination of specific clades of CTX-M-15-producing E. coli ST410 in human and animal populations.
Citation Styles
Harvard Citation style: Falgenhauer, L., Imirzalioglu, C., Ghosh, H., Gwozdzinski, K., Schmiedel, J., Gentil, K., et al. (2016) Circulation of clonal populations of fluoroquinolone-resistant CTX-M-15-producing Escherichia coli ST410 in humans and animals in Germany., International Journal of Antimicrobial Agents, 47(6), pp. 457-465. https://doi.org/10.1016/j.ijantimicag.2016.03.019
APA Citation style: Falgenhauer, L., Imirzalioglu, C., Ghosh, H., Gwozdzinski, K., Schmiedel, J., Gentil, K., Bauerfeind, R., Kämpfer, P., Seifert, H., Michael, G., Schwarz, S., Pfeifer, Y., Werner, G., Pietsch, M., Roesler, U., Guerra, B., Fischer, J., Sharp, H., Käsbohrer, A., ...Chakraborty, T. (2016). Circulation of clonal populations of fluoroquinolone-resistant CTX-M-15-producing Escherichia coli ST410 in humans and animals in Germany.. International Journal of Antimicrobial Agents. 47(6), 457-465. https://doi.org/10.1016/j.ijantimicag.2016.03.019
