Journalartikel

Jahr der Veröffentlichung: 2008

Seiten: 105-119

Zeitschrift: Expert Review of Proteomics

Bandnummer: 5

Heftnummer: 1

ISSN: 1744-8387

DOI Link: https://doi.org/10.1586/14789450.5.1.105

Verlag: Taylor and Francis Group

Abstract: 
Many phenotypic changes of eukaryotic cells due to changes in gene expression depend on alterations in chromatin structure. Processes involved in the alteration of chromatin are diverse and include post-translational modifications of histone proteins, incorporation of specific histone variants, methylation of DNA and ATP-dependent chromatin remodeling. Interconnected with these processes are the localization of chromatin domains within the nuclear architecture and the appearance of various classes of noncoding regulatory RNAs. Recent experiments underscore the role of these processes in influencing diverse biological functions. However, the evidence to date implies the importance of an interplay of all these chromatin-changing functions, generating an epigenetic regulatory circuit that is still not well understood.

Harvard-Zitierstil: Bönisch, C., Nieratschker, S., Orfanos, N. and Hake, S. (2008) Chromatin proteomics and epigenetic regulatory circuits., Expert Review of Proteomics, 5(1), pp. 105-119. https://doi.org/10.1586/14789450.5.1.105

APA-Zitierstil: Bönisch, C., Nieratschker, S., Orfanos, N., & Hake, S. (2008). Chromatin proteomics and epigenetic regulatory circuits.. Expert Review of Proteomics. 5(1), 105-119. https://doi.org/10.1586/14789450.5.1.105