Journal article

Publication year: 2016

Pages: 82-89

Journal: Current Opinion in Genetics & Development

Volume number: 37

DOI Link: https://doi.org/10.1016/j.gde.2015.12.002

Publisher: Elsevier

Abstract: 

Histone
variants have emerged as important contributors to the regulation of chromatin
structure and therefore of almost all DNA-based processes. Hence, these
specialized proteins play important roles in transcriptional regulation, cell
cycle progression, DNA repair, chromatin stability, chromosome segregation and
apoptosis. Due to their evident biological significance, it is not surprising
that mutations or the deregulation of their expression levels can have severe
implications for cellular functions that ultimately might contribute to or even
drive disease development, most notably cancer. Besides the histones
themselves, their respective chaperone/remodeling complexes needed for precise
variant chromatin deposition, are consequently frequent targets in neoplasms
and diverse diseases. In this review, we briefly summarize current
understanding on the function of human/mammalian histone variants and their
regulatory networks and highlight their roles in cancer development.

Harvard Citation style: Zink, L. and Hake, S. (2016) Histone variants: nuclear function and disease, Current Opinion in Genetics and Development, 37, pp. 82-89. https://doi.org/10.1016/j.gde.2015.12.002

APA Citation style: Zink, L., & Hake, S. (2016). Histone variants: nuclear function and disease. Current Opinion in Genetics and Development. 37, 82-89. https://doi.org/10.1016/j.gde.2015.12.002