Journal article
Authors list: Kotke, M; Schreiner, PR
Publication year: 2006
Pages: 434-439
Journal: Tetrahedron
Volume number: 62
Issue number: 2-3
ISSN: 0040-4020
DOI Link: https://doi.org/10.1016/j.tet.2005.09.079
Publisher: Elsevier
Abstract:
The acid-free, organocatalytic acetalization of various aldehydes and ketones with NN-bis[3,5-bis(trifluoromethyl)phenyl] thiourea is presented. The neutral, double hydrogen bonding thiourea catalyst can be used at very low loadings of 0.01-1 mol% at room temperature to furnish the respective acetals in 65-99% yield at turnover frequencies around 600 h(-1). Acid-labile TBDMS-protected as well as unsaturated aldehydes can be converted efficiently into their acetals utilizing this very mild and highly practical method.
Citation Styles
Harvard Citation style: Kotke, M. and Schreiner, P. (2006) Acid-free, organocatalytic acetalization, Tetrahedron, 62(2-3), pp. 434-439. https://doi.org/10.1016/j.tet.2005.09.079
APA Citation style: Kotke, M., & Schreiner, P. (2006). Acid-free, organocatalytic acetalization. Tetrahedron. 62(2-3), 434-439. https://doi.org/10.1016/j.tet.2005.09.079
