Journal article

Publication year: 2002

Pages: 295-300

Journal: Journal of Molecular Microbiology and Biotechnology

Volume number: 4

Issue number: 3

ISSN: 1464-1801

URL: https://www.caister.com/jmmb/v/v4/35.pdf

Publisher: Karger Publishers

Abstract: 
Solvent synthesis in Clostridium acetobutylicum is induced in concert with sporulation to counteract the dangerous effects of produced butyric and acetic acids and to provide the cell with sufficient time to complete endospore formation. Cardinal transcription units for butanol and acetone production are the sot and adc operons encoding butyraldehyde/butanol dehydrogenase and coenzyme A transferase as well as acetoacetate decarboxylase. Induction is achieved by a decreased level of DNA supercoiling and the transcription factor Spo0A, possibly in cooperation with other regulatory proteins. A number of other operons is also turned on during this metabolic switch, whose physiological relevance, however, is only partly understood. The recent completion of C. acetobutylicum genome sequencing will pave the way for transcriptional profiling and thus allow comprehension of the coherent regulatory networks of solvento-genesis and sporulation.

Harvard Citation style: Dürre, P., Böhringer, M., Nakotte, S., Schaffer, S., Thormann, K. and Zickner, B. (2002) Transcriptional regulation of solventogenesis in Clostridium acetobutylicum, Journal of Molecular Microbiology and Biotechnology, 4(3), pp. 295-300. https://www.caister.com/jmmb/v/v4/35.pdf

APA Citation style: Dürre, P., Böhringer, M., Nakotte, S., Schaffer, S., Thormann, K., & Zickner, B. (2002). Transcriptional regulation of solventogenesis in Clostridium acetobutylicum. Journal of Molecular Microbiology and Biotechnology. 4(3), 295-300. https://www.caister.com/jmmb/v/v4/35.pdf