Journal article

Publication year: 2012

Pages: 8-12

Journal: Transcription

Volume number: 3

Issue number: 1

ISSN: 2154-1272

DOI Link: https://doi.org/10.4161/trns.3.1.19078

Publisher: Taylor and Francis Group

Abstract: 
During transcription of protein coding genes by RNA Polymerase II the mRNA is processed and packaged into an mRNP. Among the proteins binding cotranscriptionally to the mRNP are mRNA export factors. One of the protein complexes thus coupling transcription to mRNA export is the TREX complex. However, despite the fact that TREX was identified and characterized about a decade ago, it had remained enigmatic how TREX is recruited to genes. The conserved Prp19 complex (Prp19C) has long been known for its function in splicing. We recently identified Prp19C to be essential for a second step in gene expression namely TREX occupancy at transcribed genes, answering this long-standing question but also raising new ones.

Harvard Citation style: Chanarat, S., Burkert-Kautzsch, C., Meinel, D. and Sträßer, K. (2012) Prp19C and TREX: interacting to promote transcription elongation
and mRNA export, Transcription, 3(1), pp. 8-12. https://doi.org/10.4161/trns.3.1.19078

APA Citation style: Chanarat, S., Burkert-Kautzsch, C., Meinel, D., & Sträßer, K. (2012). Prp19C and TREX: interacting to promote transcription elongation
and mRNA export. Transcription. 3(1), 8-12. https://doi.org/10.4161/trns.3.1.19078