Journalartikel

Jahr der Veröffentlichung: 2017

Seiten: 1011-1016

Zeitschrift: Current Genetics

Bandnummer: 63

Heftnummer: 6

Open Access Status: Hybrid

DOI Link: https://doi.org/10.1007/s00294-017-0710-y

Verlag: Springer

Abstract: 

Bacterial dormancy is a valuable survival strategy upon challenging
environmental conditions. Dormant cells tolerate the consequences of
high stress levels and may re-populate the environment upon return to
favorable conditions. Antibiotic-tolerant bacteria—termed
persisters—regularly cause relapsing infections, increase the likelihood
of antibiotic resistance, and, therefore, earn increasing attention.
Their generation often depends on toxins from chromosomal
toxin–antitoxin systems. Here, we review recent insights concerning
RNA-based control of toxin synthesis, and discuss possible implications
for persister generation.

Harvard-Zitierstil: Berghoff, B. and Wagner, E. (2017) RNA-based regulation in type I toxin–antitoxin systems and its implication for bacterial persistence, Current Genetics, 63(6), pp. 1011-1016. https://doi.org/10.1007/s00294-017-0710-y

APA-Zitierstil: Berghoff, B., & Wagner, E. (2017). RNA-based regulation in type I toxin–antitoxin systems and its implication for bacterial persistence. Current Genetics. 63(6), 1011-1016. https://doi.org/10.1007/s00294-017-0710-y