Journal article

Publication year: 2002

Pages: 1472-1477

Journal: Biochemical and Biophysical Research Communications

Volume number: 293

Issue number: 5

ISSN: 0006-291X

DOI Link: https://doi.org/10.1016/S0006-291X(02)00411-4

Publisher: Elsevier

Abstract: 

Interleukin-1 receptor-associated-kinases (IRAKs) are signal transduction mediators of the Toll/IL-1 receptor family, which comprise several transmembrane proteins involved in host defense mechanisms. Today four different human IRAKs (hu-IRAK-1, hu-IRAK-2, hu-IRAK-M, hu-IRAK-4) and two murine IRAKs (mouse pelle like kinase (mPLK) and mu-IRAK-4) have been described. Here we report the identification and characterization of murine IRAK-M (mu-IRAK-M), a mouse homologue to human IRAK-M (hu-IRAK-M). These IRAK-M molecules show 71% sequence identity, a comparable cellular expression, and functional similarities with respect to signal transduction capacity and kinase activity, suggesting functional homology in signalling in human and mouse cells.

Harvard Citation style: Rosati, Q. and Martin, M. (2002) Identification and characterization of murine IRAK-M, Biochemical and Biophysical Research Communications, 293(5), pp. 1472-1477. https://doi.org/10.1016/S0006-291X(02)00411-4

APA Citation style: Rosati, Q., & Martin, M. (2002). Identification and characterization of murine IRAK-M. Biochemical and Biophysical Research Communications. 293(5), 1472-1477. https://doi.org/10.1016/S0006-291X(02)00411-4