Journal article

Publication year: 2012

Pages: S86-S86

Journal: Toxicology Letters

Volume number: 211

Issue number: Supplement

ISSN: 0378-4274

DOI Link: https://doi.org/10.1016/j.toxlet.2012.03.327

Publisher: Elsevier

Abstract: 

The decabromodiphenyl
ether (decaBDE) technical product interferes with the retinoid system.
Therefore the objectives of the present study were to further
characterize the retinoid system modulation induced by decaBDE and to
evaluate retinoid alterations in relation to previously published
treatment-related effects (van der Ven et al., 2008), as well as to
human exposure data.

Wistar rats, 5 males and 5
females per dose-group were treated with purified technical product
decaBDE for 28 days (OECD 407) and retinoids were determined by HPLC.
Dose-response relationships were described with Benchmark Dose Modeling
for all-trans-retinoic acid (all-trans-RA), and
9-cis-4-oxo-13,14-dihydroretinoic acid (9c-4o-13,14-dh-RA). Association
between hepatic retinoid alteration and treatment related effects was
performed using a multivariate partial least squares regression (PLS).
Margins of exposure (MOEs) were computed based on animal tissue retinoid
alterations and CYP induction by decaBDE and human BDE-exposure levels.

We
found treatment-related decreases of the hepatic levels of all-trans-RA
and its functional 9-c-4-o-13,14-dh-RA metabolite, whereas apolar
retinoids, retinol and retinyl palmitate did not show any significant
change. MOEs were in the ranges of 0.4-1926 as calculated by using
hepatic all-trans-RA, 9-c-4-o-13,14-dh-RA levels, CYP1A, CYP2B mRNA
expression, EROD and PROD activities along with human BDE-exposure
levels for electronics dismantling workers, fish-consumers from a
contaminated lake and general population. For the e-waste recycling
workers, less than total assessment factors of 25 were obtained for all
end-points, which was considered a non-acceptable risk. The retinoid
system modulations in 28-days repeat dose study occur at dose-levels
that are of relevance to human exposure situations.

Harvard Citation style: Asencio, J., Litens, S., Barber, X., Rendel, F., Roos, R., van der Ven, L., et al. (2012) Technical decabromodiphenyl ether exposure induce retinoid system changes, Toxicology Letters, 211(Supplement), p. S86. https://doi.org/10.1016/j.toxlet.2012.03.327

APA Citation style: Asencio, J., Litens, S., Barber, X., Rendel, F., Roos, R., van der Ven, L., Hamscher, G., Esteban, J., & Hakansson, H. (2012). Technical decabromodiphenyl ether exposure induce retinoid system changes. Toxicology Letters. 211(Supplement), S86. https://doi.org/10.1016/j.toxlet.2012.03.327