Journalartikel

Jahr der Veröffentlichung: 2005

Seiten: 1265-1271

Zeitschrift: Biological Chemistry

Bandnummer: 386

Heftnummer: 12

ISSN: 1431-6730

eISSN: 1437-4315

DOI Link: https://doi.org/10.1515/BC.2005.143

Verlag: De Gruyter Brill

Abstract: 
Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct protein products. This is accomplished by the differential recognition of splice sites in the pre-mRNA, often regulated in a tissue - or development-specific manner. Alternative splicing constitutes not only an important mechanism in controlling gene expression in humans, but also an essential source for increasing proteome diversity. In this review we summarize the underlying mechanistic principles, focussing on the cis-acting regulatory elements. In particular, the role of short sequence repeats, which are often polymorphic, in splicing regulation is discussed.

Harvard-Zitierstil: Hui, J. and Bindereif, A. (2005) Alternative pre-mRNA splicing in the human system: unexpected role of repetitive sequences as regulatory elements, Biological Chemistry, 386(12), pp. 1265-1271. https://doi.org/10.1515/BC.2005.143

APA-Zitierstil: Hui, J., & Bindereif, A. (2005). Alternative pre-mRNA splicing in the human system: unexpected role of repetitive sequences as regulatory elements. Biological Chemistry. 386(12), 1265-1271. https://doi.org/10.1515/BC.2005.143