Journal article

Publication year: 2002

Pages: 1063-1069

Journal: Journal of Experimental Medicine

Volume number: 195

Issue number: 8

ISSN: 0022-1007

DOI Link: https://doi.org/10.1084/jem.20012059

Publisher: Rockefeller University Press

Abstract: 
Peptide acquisition by MHC class II molecules is catalyzed by HLA-DM (DM). In B cells, HLA-DO (DO) inhibits or modifies the peptide exchange activity of DM. We show here that DO protein levels are modulated during B cell differentiation. Remarkably, germinal center (GC) B cells, which have low levels of DO relative to naive and memory B cells, are shown to have enhanced antigen presentation capabilities. DM protein levels also were somewhat reduced in GC B cells; however, the ratio of DM to DO in GC B cells was substantially increased, resulting in more free DM in GC B cells. We conclude that modulation of DM and DO in distinct stages of B cell differentiation represents a mechanism by which B cells regulate their capacity to function as antigen-presenting cells. Efficient antigen presentation in GC B cells would promote GC B cell-T cell interactions that are essential for B cells to survive positive selection in the GC.

Harvard Citation style: Glazier, K., Hake, S., Tobin, H., Chadburn, A., Schattner, E. and Denzin, L. (2002) Germinal center B cells regulate their capability to present antigen by modulation of HLA-DO, Journal of Experimental Medicine, 195(8), pp. 1063-1069. https://doi.org/10.1084/jem.20012059

APA Citation style: Glazier, K., Hake, S., Tobin, H., Chadburn, A., Schattner, E., & Denzin, L. (2002). Germinal center B cells regulate their capability to present antigen by modulation of HLA-DO. Journal of Experimental Medicine. 195(8), 1063-1069. https://doi.org/10.1084/jem.20012059