High CA repeat numbers in intron 13 of the endothelial nitric oxide synthase gene and increased risk of coronary artery disease - Research portal of Justus Liebig University Giessen:

Journal article

High CA repeat numbers in intron 13 of the endothelial nitric oxide synthase gene and increased risk of coronary artery disease

Authors list: Stangl, K; Cascorbi, I; Laule, M; Klein, T; Stangl, V; Rost, S; Wernecke, KD; Felix, SB; Bindereif, A; Baumann, G; Roots, I

Publication year: 2000

Pages: 133-140

Journal: Pharmacogenetics

Volume number: 10

Issue number: 2

ISSN: 0960-314X

DOI Link: https://doi.org/10.1097/00008571-200003000-00005

Publisher: Lippincott Williams & Wilkins

Abstract:
Endothelial nitric oxide synthase (eNOS) plays a key role in vascular homeostasis. Because its product, nitric oxide, possesses vasodilatory and antiatherogenic properties, an altered eNOS function might promote atherosclerosis. We investigated the association between variations in CA repeat copy number [(CA), polymorphism] in intron 13 of the eNOS gene and the risk of coronary artery disease. (CA), polymorphism was investigated in 1000 consecutive patients with angiographically confirmed coronary artery disease and 1000 age- and gender-matched control subjects by a PCR-based fragment length calculation. Twenty-eight different alleles were identified containing 17-44 CA repeats. The presence of one allele containing > or = 38 repeats was associated with an excess risk of coronary artery disease (odds ratio 1.94, 95% confidence interval 1.31-2.86, P = 0.001). Carriers of alleles containing > or = 38 CA repeats were, in particular, overrepresented in the subgroup without common cardiovascular risk factors (odds ratio 3.39, 95% confidence interval 1.30-8.86, P = 0.009). Logistic regression analysis revealed that the (CA), polymorphism proved to be an independent risk factor (relative risk 2.17, 95% confidence interval 1.44-3.27, P = 0.0002). Our findings indicate that high numbers of CA repeats in intron 13 of the eNOS gene are associated with an excess risk of coronary artery disease.

Citation Styles

Harvard Citation style: Stangl, K., Cascorbi, I., Laule, M., Klein, T., Stangl, V., Rost, S., et al. (2000) High CA repeat numbers in intron 13 of the endothelial nitric oxide synthase gene and increased risk of coronary artery disease, Pharmacogenetics, 10(2), pp. 133-140. https://doi.org/10.1097/00008571-200003000-00005

APA Citation style: Stangl, K., Cascorbi, I., Laule, M., Klein, T., Stangl, V., Rost, S., Wernecke, K., Felix, S., Bindereif, A., Baumann, G., & Roots, I. (2000). High CA repeat numbers in intron 13 of the endothelial nitric oxide synthase gene and increased risk of coronary artery disease. Pharmacogenetics. 10(2), 133-140. https://doi.org/10.1097/00008571-200003000-00005