Sammelbandbeitrag

Pre-mRNA Splicing in Trypanosoma brucei: Factors, Mechanisms, and Regulation


AutorenlistePreußer, C; Jae, N; Günzö, A; Bindereif, A

Erschienen inRNA Metabolism in Trypanosomes

HerausgeberlisteBindereif, A

Jahr der Veröffentlichung2012

Seiten49-77

ISBN978-3-642-28686-5

eISBN978-3-642-28687-2

DOI Linkhttps://doi.org/10.1007/978-3-642-28687-2_3

Auflage1

SerientitelNucleic Acids and Molecular Biology

Serienzählung28


Abstract
Processing of polycistronic pre-mRNAs in trypanosomes requires trans splicing and polyadenylation of the primary transcripts to generate mature 5′ and 3′ ends of the mRNAs, respectively. Splicing is catalyzed by the spliceosome, which contains the spliceosomal small nuclear ribonucleoprotein particles (snRNPs) U1, U2, U4/U6, and U5, as well as the SL RNP, which is essential for trans splicing. As in other eukaryotes, the trypanosomal snRNPs share a common set of seven Sm polypeptides, which assemble in a ring-like structure on the Sm binding site of the snRNAs, a process that is mediated by the survival of motor neurons (SMN) protein. Whereas studies in the last decade disclosed numerous spliceosomal components, little is known about splicing regulation in trypanosomes, even though recent studies revealed evidence for alternative trans splicing. Here we summarize the current state of research on mRNA splicing in Trypanosoma brucei which differs in several aspects from the well-studied mechanisms in other eukaryotes.




Zitierstile

Harvard-ZitierstilPreußer, C., Jae, N., Günzö, A. and Bindereif, A. (2012) Pre-mRNA Splicing in Trypanosoma brucei: Factors, Mechanisms, and Regulation, in Bindereif, A. (ed.) RNA Metabolism in Trypanosomes. 1. Berlin, Heidelberg: Springer Verlag, pp. 49-77. https://doi.org/10.1007/978-3-642-28687-2_3

APA-ZitierstilPreußer, C., Jae, N., Günzö, A., & Bindereif, A. (2012). Pre-mRNA Splicing in Trypanosoma brucei: Factors, Mechanisms, and Regulation. In Bindereif, A. (Ed.), RNA Metabolism in Trypanosomes (1, pp. 49-77). Springer Verlag. https://doi.org/10.1007/978-3-642-28687-2_3


Zuletzt aktualisiert 2025-21-05 um 15:04