Journal article

Publication year: 2014

Pages: 167-174

Journal: Chemosphere

Volume number: 100

ISSN: 0045-6535

DOI Link: https://doi.org/10.1016/j.chemosphere.2013.11.038

Publisher: Elsevier

Abstract: 
This study assessed the photochemical fate of nine sulfonamides (sulfamerazine, sulfanilamide, sulfamethoxypyridazine, sulfamethoxazole, sulfachloropyridazine, sulfamethazine, sulfadiazine, sulfathiazole and sulfadimethoxine) during a 6h irradiation period with UVA/UVB-light and UVA-light and over 7 days under natural (sunlight) conditions. The cell growth inhibition effect and cytotoxicity of sulfonamides and their photodegradation products was investigated over 24 and 48 h with murine fibroblasts and keratinocytes. Antibacterial activity of the degradation products was studied using the Geobacillus stearothermophilus var. Calidolactis C953 assay.
UVA/UVB treatment of several sulfonamide solutions results in degradation of the compounds in different amounts with the highest degradation rate for sulfathiazole and sulfanilamide. The UVA/UVB light degradation products exhibit no antimicrobial activity. Sun light exposure over 7 days reveals a similar degradation pattern of the different sulfonamides, albeit to a different extent. Compared with UVA/UVB-irradiation, UVA-irradiated sulfonamides degrade to a lesser extent (except sulfamethazine). There was no impact on cell toxicity of the UVA/UVB-degrading products except for sulfanilamide, while a slight impact on cell proliferation was observed.
All studied sulfonamides undergo photodegradation under UV-light exposure to a greater or lesser extent. The degradation products have no cytotoxic potential except sulfanilamide and have a slight impact on cell proliferation. All degradation products showed no antibacterial activity. Thus, UV-light exposure seems to represent an adequate method for inactivating sulfonamides with regard to their antimicrobial activity.

Harvard Citation style: Zessel, K., Mohring, S., Hamscher, G., Kietzmann, M. and Stahl, J. (2014) Biocompatibility and antibacterial activity of photolytic products of sulfonamides, Chemosphere, 100, pp. 167-174. https://doi.org/10.1016/j.chemosphere.2013.11.038

APA Citation style: Zessel, K., Mohring, S., Hamscher, G., Kietzmann, M., & Stahl, J. (2014). Biocompatibility and antibacterial activity of photolytic products of sulfonamides. Chemosphere. 100, 167-174. https://doi.org/10.1016/j.chemosphere.2013.11.038