Journal article

Publication year: 2012

Pages: 221-224

Journal: International Journal of Medical Microbiology

Volume number: 302

Issue number: 4-5

ISSN: 1438-4221

DOI Link: https://doi.org/10.1016/j.ijmm.2012.07.004

Publisher: Elsevier

Abstract: 
The parasitic unicellular trypanosomatids are responsible for several fatal diseases in humans and livestock. Regarding their biochemistry and molecular biology, they possess a multitude of special features such as polycistronic transcription of protein-coding genes. The resulting long primary transcripts need to be processed by coupled trans-splicing and polyadenylation reactions, thereby generating mature mRNAs. Catalyzed by a large ribonucleoprotein complex termed the spliceosome, trans-splicing attaches a 39-nucleotide leader sequence, which is derived from the Spliced Leader (SL) RNA, to each protein-coding gene. Recent genome-wide studies demonstrated that alternative trans-splicing increases mRNA and protein diversity in these organisms. In this mini-review we give an overview of the current state of research on trans-splicing.

Harvard Citation style: Preußer, C., Jae, N. and Bindereif, A. (2012) mRNA splicing in trypanosomes, International Journal of Medical Microbiology, 302(4-5), pp. 221-224. https://doi.org/10.1016/j.ijmm.2012.07.004

APA Citation style: Preußer, C., Jae, N., & Bindereif, A. (2012). mRNA splicing in trypanosomes. International Journal of Medical Microbiology. 302(4-5), 221-224. https://doi.org/10.1016/j.ijmm.2012.07.004