Journal article

Publication year: 1995

Pages: 129-133

Journal: Gene

Volume number: 161

Issue number: 1

ISSN: 0378-1119

DOI Link: https://doi.org/10.1016/0378-1119(95)00247-4

Publisher: Elsevier

Abstract: 
We have isolated and sequenced the genes for the a trans-spliceosomal U6 small nuclear RNAs (snRNAs) from the trypanosomatid species Leishmania mexicana (Lm) and Phytomonas sp. (Ps). Compared with the Trypanosoma brucei (Tb) U6 snRNA, the Lm U6 snRNA contains only a single additional G-C bp in the 5' terminal stem-loop. In contrast, the Ps U6 snRNA sequence contains a G-->C change at the last nucleotide of the highly conserved and functionally important ACAGAG hexanucleotide and three additional changes in conserved positions. Our results indicate that trans-spliceosomal U6 snRNAs from trypanosomatid species do not always conform to the consensus sequence of cis-spliceosomal U6 snRNAs.

Harvard Citation style: Wieland, B. and Bindereif, A. (1995) Unexpected diversity in U6 snRNA sequences from trypanosomatids., Gene, 161(1), pp. 129-133. https://doi.org/10.1016/0378-1119(95)00247-4

APA Citation style: Wieland, B., & Bindereif, A. (1995). Unexpected diversity in U6 snRNA sequences from trypanosomatids.. Gene. 161(1), 129-133. https://doi.org/10.1016/0378-1119(95)00247-4