Journalartikel

Jahr der Veröffentlichung: 2002

Seiten: 1616-1626

Zeitschrift: Gastroenterology

Bandnummer: 123

Heftnummer: 5

ISSN: 0016-5085

DOI Link: https://doi.org/10.1053/gast.2002.36590

Verlag: Elsevier

Abstract: 
Background & Aims: Xenin is a 25-amino acid peptide produced by specific endocrine cells of the duodenal mucosa. We investigated whether xenin is expressed in neuroendocrine tumors. Methods: Seventy-two foregut and midgut neuroendocrine tumors were examined by means of immunohistochemistry, confocal laser microscopy with an antibody against the C-terminus of xenin, and high-pressure liquid chromatography after acidic extraction, assessed by radioimmunoassay. Results: We found xenin-immunoreactive cells in 23 of 26 duodenal neuroendocrine tumors, including gastrinomas, somatostatinomas, and nonfunctioning and enterochromaffin cell tumors. In these tumors, up to 20% of the endocrine cells were xenin immunoreactive, and xenin immunoreactivity was concentrated in secretory granules. Xenin was coexpressed with chromogranin A. We found no xenin expression in gastrin-, somatostatin-, and serotonin-immunoreactive cells. High-pressure liquid chromatography after acidic extraction revealed 497 +/- 285 pmol of xenin per gram of tissue in 5 duodenal gastrinomas. The other neuroendocrine tumors, such as bronchial carcinoids, gastric enterochromaffin-like cell carcinoids, gastric and ileal enterochromaffin cell carcinoids, insulinomas, and gastrinomas of pancreatic origin, did not contain immunoreactive xenin. Conclusions: Xenin is a peptide marker specific to neuroendocrine tumors of the duodenum. This finding may be useful in tumor classification and in the differential diagnosis of neuroendocrine tumors of the upper gut.

Harvard-Zitierstil: Feurle, G., Anlauf, M., Hamscher, G., Arnold, R., Klöppel, G. and Weihe, E. (2002) Xenin-immunoreactive cells and extractable xenin in neuroendocrine tumors of duodenal origin, Gastroenterology, 123(5), pp. 1616-1626. https://doi.org/10.1053/gast.2002.36590

APA-Zitierstil: Feurle, G., Anlauf, M., Hamscher, G., Arnold, R., Klöppel, G., & Weihe, E. (2002). Xenin-immunoreactive cells and extractable xenin in neuroendocrine tumors of duodenal origin. Gastroenterology. 123(5), 1616-1626. https://doi.org/10.1053/gast.2002.36590