Journal article

Publication year: 2016

Pages: 227-234

Journal: Environmental Microbiology Reports

Volume number: 8

ISSN: 1758-2229

eISSN: 1758-2229

Open access status: Hybrid

DOI Link: https://doi.org/10.1111/1758-2229.12372

Publisher: Wiley

Abstract: 
Bacterial populations differentiate at the subspecies level into clonal complexes. Intraclonal genome diversity was studied in 100 isolates of the two dominant Pseudomonas aeruginosa clones C and PA14 collected from the inanimate environment, acute and chronic infections. The core genome was highly conserved among clone members with a median pairwise within-clone single nucleotide sequence diversity of 8x10(-6) for clone C and 2x10(-5) for clone PA14. The composition of the accessory genome was, on the other hand, as variable within the clone as between unrelated clones. Each strain carried a large cargo of unique genes. The two dominant worldwide distributed P. aeruginosa clones combine an almost invariant core with the flexible gain and loss of genetic elements that spread by horizontal transfer.

Harvard Citation style: Fischer, S., Klockgether, J., Losada, P., Chouvarine, P., Cramer, N., Davenport, C., et al. (2016) Intraclonal genome diversity of the major Pseudomonas aeruginosa clones C and PA14, Environmental Microbiology Reports, 8, pp. 227-234. https://doi.org/10.1111/1758-2229.12372

APA Citation style: Fischer, S., Klockgether, J., Losada, P., Chouvarine, P., Cramer, N., Davenport, C., Dethlefsen, S., Dorda, M., Goesmann, A., Hilker, R., Mielke, S., Schönfelder, T., Suerbaum, S., Türk, O., Woltemate, S., Wiehlmann, L., & Tümmler, B. (2016). Intraclonal genome diversity of the major Pseudomonas aeruginosa clones C and PA14. Environmental Microbiology Reports. 8, 227-234. https://doi.org/10.1111/1758-2229.12372