Journalartikel

Jahr der Veröffentlichung: 2012

Seiten: S85-S86

Zeitschrift: Toxicology Letters

Bandnummer: 211

Heftnummer: Supplement

ISSN: 0378-4274

DOI Link: https://doi.org/10.1016/j.toxlet.2012.03.326

Verlag: Elsevier

Abstract: 

Background exposure to
polychlorinated biphenyls (PCBs) nowadays mainly occurs via food.
Knowledge about the impact of exposure to individual PCB congeners in
early life stages is limited. Therefore, the non-dioxin-like (NDL) PCBs
52 (2,2′,5,5′-tetrachlorobiphenyl) and 180
(2,2′,3,4,4′,5,5′-heptachlorbiphenyl), two of the most abundant PCBs,
were tested in in utero/lactational studies to contribute to the
knowledge about PCB-toxicity profiles.

Pregnant Sprague–Dawley rats were given during gestation PCB52 or PCB180 at daily total oral doses from 0 to 3000 mg/kg b.w. or 0 to 1000 mg/kg
b.w., respectively. One pup/sex/litter was sacrificed at PND7, 35 or 84
and evaluated for effects on organ weights, retinoid levels and enzyme
activities. Furthermore, benchmark doses (BMD) were calculated.

PCB180
exposure, dose dependently affected various organ weights, hepatic
enzyme activities and retinoid levels in offspring. The most sensitive
endpoint was increased relative liver weight with a BMD of 35.8 mg/kg b.w. for female PND7 offspring and decreased hepatic retinol concentration of PND35 female offspring with a BMD of 7 mg/kg b.w. Furthermore PCB180 induced CYP1A- and CYP2B-activities, with BMDs of 178 and 9 mg/kg
b.w., respectively, for PND7 female offspring. Effects of PCB52 were
less pronounced, except for the retinoid metabolite
9-cis-4-oxo-13,14-dihydro retinoic acid, for which the calculated BMD
was 8 mg/kg b.w. as compared to 62 mg/kg b.w. for PCB180 in PND35 female
offspring. Our findings demonstrate that oral exposure of pregnant rats
to NDL-PCBs 52 and 180 in the mg/kg b.w. per day range has significant
effects in the offspring.

Harvard-Zitierstil: Roos, R., Rendel, F., Herlin, M., Hamscher, G., Halldin, K., Schrenk, D., et al. (2012) Toxicological profiles of two abundant PCBs in rat offspring, Toxicology Letters, 211(Supplement), pp. S85-S86. https://doi.org/10.1016/j.toxlet.2012.03.326

APA-Zitierstil: Roos, R., Rendel, F., Herlin, M., Hamscher, G., Halldin, K., Schrenk, D., Hakansson, H., & Viluksela, M. (2012). Toxicological profiles of two abundant PCBs in rat offspring. Toxicology Letters. 211(Supplement), S85-S86. https://doi.org/10.1016/j.toxlet.2012.03.326